Will there be a catastrophic future war in the Middle East?

Where nuclear weapons will be used. And leaves Tel Aviv, Damascus and Teheran looking like Dresden of 1945, or worse: Hiroshima and Nagasaki of the same fateful year? I think it can happen. The Muslim Arabs have not renounced in getting Palestine [i.e. "Israel"] back, and the Israelis have not renounced in keeping it. Sooner or later a big bang is going to happen. Hundred of thousands killed on both sides, including women and children. Dreadful. What do you think?